LSU vs. Missouri odds, spread, line: 2023 college football picks, Week 6 predictions from proven computer

Four matchups between ranked teams are on the Week 6 college football schedule, and one such battle takes place in Columbia, Missouri. Memorial Stadium hosts an SEC tilt between the No. 21 Missouri Tigers and the No. 23 LSU Tigers. Missouri aims to remain unbeaten, with the team winning its first five games for the first time since the 2013 season. LSU looks to bounce back from a close-fought loss to Ole Miss last week and improve on a 3-2 mark to begin the 2023 season.

SportsLine consensus lists LSU as a 5.5-point favorite for this noon ET kickoff. The total number of points Vegas thinks will be scored, or the over/under, is 64.5 in the latest LSU vs. Missouri odds via SportsLine consensus. Before making any Missouri vs. LSU picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Missouri and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several college football odds and betting lines for Missouri vs. LSU:

  • LSU vs. Missouri spread: LSU -5.5
  • LSU vs. Missouri over/under: 64.5 points
  • LSU vs. Missouri money line: LSU -229, Missouri +186
  • LSU: 2-3 against the spread this season
  • MIZ: 3-2 against the spread this season
  • LSU vs. Missouri picks: See picks at SportsLine
  • LSU vs. Missouri live stream: fubo (try for free)

Why LSU can cover

LSU’s passing game is virtually impossible to defend. The offense is led by quarterback Jayden Daniels, who is a candidate for the Heisman Trophy. Daniels is No. 2 in FBS with 400.4 total yards per game and 16 passing touchdowns, and he ranks in the top five of the country with 342.0 passing yards per game and a 193.4 mark in passing efficiency. Daniels is completing 73.1% of his passes with only two interceptions and, in the last four games, he has 18 touchdown passes and only one interception. 

Daniels is the catalyst, but he is flanked by two elite wide receivers. Malik Nabers has 29 catches for 471 yards and four touchdowns in the last three games alone, including a 13-catch, 239-yard performance in a win over Mississippi State. On the other side, Brian Thomas is tied for the FBS lead for eight receiving touchdowns, and he has 13 catches for 257 yards and five touchdowns in the last two games. Led by the passing attack, LSU ranks in the top seven of the country in scoring offense (44.0 points per game), total offense (551.4 yards per game), yards per play (7.8) and third down efficiency (57.6%). See which team to pick here.

Why Missouri can cover

Missouri has a high-powered offense, but the defensive side is where the team may have advantages against LSU. While Missouri’s defense is playing well, LSU is second-worst in the SEC in allowing 31.0 points per game and 429.4 total yards per game this season. LSU also ranks outside the top 100 of FBS in points allowed, total yards allowed, touchdown passes allowed, rushing yards allowed, and pass efficiency allowed this season, while generating the third-fewest sacks (nine) among SEC teams. 

On Missouri’s side, opponents are averaging only 20.8 points per game and 5.0 yards per play, comfortably landing above the average in both the SEC and FBS. Missouri is also elite against the run, leading the conference in rushing yards allowed per game (74.8) and per attempt (2.5). With Brady Cook leading a potent offense and Missouri playing at home in Columbia, the Tigers can enter this matchup with confidence against a talented opponent. See which team to pick here.

How to make LSU vs. Missouri picks

SportsLine’s model is leaning Under on the point total, with neither team projected to reach its season-long scoring average. The model also says one side of the spread hits in more than 50% of simulations. You can only see the model’s pick at SportsLine.

So who wins LSU vs. Missouri, and which side of the spread hits in more than 50% of simulations? Visit SportsLine now to find out which side of the LSU vs. Missouri spread you need to jump on Saturday, all from the model has generated a profit of more than $2,000 for $100 players, and find out.  

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